Coagulation

Coagulation (clotting) is the process by which blood changes from a liquid to a gel. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion, and aggregation of platelets along with deposition and maturation of fibrin. Disorders of coagulation are disease states which can result in bleeding (hemorrhage or bruising) or obstructive clotting (thrombosis).
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Activated Protein C Resistance

Activated Protein C Resistance

£70.00
Ex Tax: £70.00
Factor V Leiden mutation is the most common inherited predisposition to abnormal clotting. It occurs in about 10% in Caucasian population. The Factor V Leiden mutation may be heterozygous (has one copy of the changed gene and one normal gene) or homozygous (has two copies of the changed gene; this is more rare). Those who are heterozygous...
Antithrombin III

Antithrombin III

£51.00
Ex Tax: £51.00
Antithrombin is a protein produced by the liver to help control blood clotting. Normally, when a blood vessel is injured, the body activates a series of coagulation factors, in a process called the coagulation cascade, to form a blood clot and prevent further blood loss. Antithrombin helps to regulate this process by inhibiting the action...
APTT/KCCT

APTT/KCCT

£31.00
Ex Tax: £31.00
The activated partial thromboplastin time (aPTT or PTT) is a measure of a persons clotting ability. The body uses a coagulation cascade to produce blood clots to seal off injuries to blood vessels and tissues, to prevent further blood loss, and to give the damaged areas time to heal. Each component of the coagulation cascade must be func...
Clotting Screen

Clotting Screen

£41.00
Ex Tax: £41.00
This test times how long it takes for blood to clot when exposed to different substances. Prolonged times indicate an increased risk of bleeding or activation of the clotting system......
D-Dimers (Fibrinogen Degradation Products)

D-Dimers (Fibrinogen Degradation Products)

£35.00
Ex Tax: £35.00
The main use of D-Dimer is in excluding venous blood clots as a cause for symptoms in the legs or lungs – it has something called 'negative predictive value'. If your D-dimer result is negative it is extremely unlikely you have a significant venous blood clot. D-dimer has no 'positive predictive value' – it is raised in many conditions an...
Factor V Leiden, MTHFR, Prothrombin mutations

Factor V Leiden, MTHFR, Prothrombin mutations

£180.00
Ex Tax: £180.00
Factor V Leiden, MTHFR mutations and Prothrombin mutations have all been linked to a risk of venous thrombosis. This triple test detects all 3 mutations. .....
Fibrinogen

Fibrinogen

£45.00
Ex Tax: £45.00
Fibrinogen is a coagulation factor. Normally, when a body tissue or blood vessel wall is injured a process called the coagulation cascade activates and as the cascade nears completion, soluble fibrinogen (fibrinogen dissolved in fluid) is changed into insoluble fibrin threads. These threads cross-link to form a fibrin net and then stabili...
INR

INR

£31.00
Ex Tax: £31.00
This is a tightly controlled version of the PT called the International Normalised Ratio (INR) which is used to measure the effect of anticoagulant drugs such as warfarin......
Protein C

Protein C

£51.00
Ex Tax: £51.00
Proteins C helps adjust the rate of blood clot formation. When a blood vessel or tissue is injured a blood clot forms. This clot prevents additional blood loss and protects the injury until it heals. Once it is no longer needed other factors break the clot down so that it can be removed. Protein C then combines with Protein S and together...